Specifically, I am interested in the role that nrp2a, nrp2b, and sema3fa play in the differential axon targeting of OMP and TRPC2 expressing olfactory sensory neurons.I am currently working on determining the function of a previously uncharacterized circadian oscillating long noncoding RNA (lncRNA) that may modulate the degradation of an important chromatin modifying complex. Altered cellular metabolism that promotes tumor growth represents a common feature in HCC. In 1994, she began postdoctoral research at Princeton University in the laboratory of Arnold J. Levine, Ph.D., the co-discoverer of p53 and a pioneer in the field of tumor suppressor genes and cancer biology. The Wistar Institute is an international leader in biomedical research with special expertise in cancer, immunology, infectious diseases and vaccine development. Principal Investigators are matched with Business Advisors with relevant domain expertise. Thesis Lab: Maureen Murphy . Graduate Group Affiliations Cell and Molecular Biology; Biochemistry and Molecular Biophysics; Contact information. }, year = {1999}} My thesis topic is to characterize the multimeric forms of integrase that are relevant for understanding mechanisms of action and resistance to antiretroviral therapy.I will utilize mouse genetics and metabolic assays to determine how BAT blood flow is regulated uponcold exposure. In particular, I will focus on the role of two novel targets in regulating BAT blood flow and how the thermogenic program regulates their expression. Lucie Guo (MD/PhD, matriculated 2012) B.A., 2010 (Biochemical Sciences) Harvard University Thesis Lab: Ben Black. We identified a novel series of inhibitors for HSP70 that are potent and effective anti-cancer agents. Her research focuses on the tumor suppressor genes p53 and p14arf.. Murphy's research on p53 has indicated that the gene is able to suppress tumors by inducing apoptosis in cells where DNA damage has occurred. All in all I am examining how immune responses capable of clearing intracellular pathogens are initiated.Showing {startItem} to {endItem} of {itemsNumber} matching studentsMy thesis is focused on studying the developmental ontogeny and maturation process of alveolar type one cells in the lung.My lab uses the developing olfactory system of larval zebrafish as a model to study the formation of neural circuitry. Cancer Biology Degree: PhD Matriculation Year: 2014. The outcome to date? Our studies in this area seek to improve PET-16 as an anti-cancer compound, with the goal of positioning our HSP70 inhibitors for eventual use in humans.The Murphy laboratory focuses on two cancer-critical proteins involved in tumor cell survival and death: HSP70 and p53. It has been well-known for decades that changes in these mechanical forces can contribute to heart disease, but the mechanism by which changes to stress and strain cause pathology remains unclear. I am using proteomics, live imaging and gene editing to identify novel components of the Bb and discover their function.Hepatocellular carcinoma (HCC) is the second most lethal type of cancer in the world and lacks effective targeted therapies, in part, due to its genetic heterogeneity.